Abstract Title:

Bovine lactoferrin can decrease the in vitro biofilm production or shown synergy with antibiotics against Listeria and Escherichia coli isolates.

Abstract Source:

Protein Pept Lett. 2020 04 3. Epub 2020 Apr 3. PMID: 32242775

Abstract Author(s):

Karla Alejandra García-Borjas, Ivonne Ceballos-Olvera, Sarahí Luna-Castro, Yosahandy Peña-Avelino

Article Affiliation:

Karla Alejandra García-Borjas


BACKGROUND: Bovine lactoferrin (bLf) has been reported as antimicrobial, antiviral, immunomodulatory and anticancer protein. Escherichia coli and Listeria spp. are food-borne bacteria that can produce illness in human being and mammals, the emergent antimicrobial drug resistance has been reported in these pathogens.

OBJECTIVE: The aim for this study was to evaluate the bLf effect on in vitro biofilm production and the synergic effect of antibiotics on E. coli and Listeria isolates.

METHODS: E. coli and Listeria specimens were isolated from bovine carcasses and slaughterhouses surfaces, respectively. Biofilm formation was analyzed with or without bLf, incubated for 48 h and spectrophotometry, cell viability was analyzed by colony-forming unit (CFU) and the synergistic effect of bLf with ampicillin, oxytetracycline, and streptomycin was evaluated through the fractional concentration index (FCI).

RESULTS: Our results show that a low bLf concentration (0.8μM) can diminish the in vitro biofilm production in Listeria isolates; also improves the in vitro oxytetracycline and streptomycin activity against E. coli, and ampicillin activity against Listeria isolates.

CONCLUSION: bLf can affect the biofilm production in Listeria isolates from slaughterhouses surfaces and shown synergic effect with ampicillin. Also has a synergic effect with oxytetracycline and streptomycin against E. coli isolates from bovine carcasses.

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