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Abstract Title:

Acute effect of bisphenol A: Signaling pathways on calcium influx in immature rat testes.

Abstract Source:

Reprod Toxicol. 2018 Apr ;77:94-102. Epub 2018 Feb 21. PMID: 29476780

Abstract Author(s):

Renata Gonçalves, Ana Paula Zanatta, Fernanda Carvalho Cavalari, Monica Andressa Wessner do Nascimento, Christelle Delalande-Lecapitaine, Hélène Bouraïma-Lelong, Fátima Regina Mena Barreto Silva

Article Affiliation:

Renata Gonçalves

Abstract:

We investigated the acute effect of low concentrations of BPA on calcium influx and the mechanism of action of BPA in this rapid response in the rat testis. BPA increased calcium influx at 1 pM and 1 nM at 300 s of incubation, in a similar manner to that of estradiol. At 1 pM, BPA stimulated calcium influx independently of classical estrogen receptors, consistent with a G-protein coupled receptor. This effect also involves the modulation of ionic channels, such as K, TRPV1 and Clchannels. Furthermore, BPA is able to modulate calcium from intracellular storages by inhibiting SERCA and activating IPreceptor/Cachannels at the endoplasmic reticulum and activate kinase proteins, such as PKA and PKC. The rapid responses of BPA on calcium influx could, in turn, trigger a cross talk by MEK and p38activation and also mediate genomic responses.

Study Type : Animal Study
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