Article Publish Status: FREE
Abstract Title:

Effects of Exposure to Bisphenol A during Pregnancy on the Pup Testis Function.

Abstract Source:

Int J Endocrinol. 2019 ;2019:6785289. Epub 2019 May 21. PMID: 31263496

Abstract Author(s):

Qingtao Yang, Xuxia Sui, Junjun Cao, Caixia Liu, Shukai Zheng, Mian Bao, Yuanni Huang, Kusheng Wu

Article Affiliation:

Qingtao Yang


Testosterone plays an important prenatal role in male testis development. Bisphenol A (BPA) exposure during pregnancy affects testosterone levels and germ cell apoptosis of male pups, but little information is available for the mechanism. The aim of the present study was to investigate the mechanism by which BPA alters testosterone levels and germ cell apoptosis. Pregnant female C57BL/6J mice, throughout gestation, had access to drinking water containing BPA at 5 and 50g/mL. Male pups were euthanized on postnatal days (PNDs) 1, 14, and 35. Relative to control, BPA exposure at 5 and 50g/ml decreased testosterone level, as measured by chemiluminescent immunoassay, on PND14. Real-time PCR indicated mRNA levels for steroidogenic acute regulatory protein (StAR), cholesterol side-chain cleavage enzyme (CYP11A1), and 3--hydroxysteroid dehydrogenase/-5-4 isomerase (3-HSD) were significantly lower in the BPA pups compared to control. Additionally, BPA increased the percentage of TUNEL-positive seminiferous tubules, decreased the mRNA level of Bcl-2, and increased Bax expression, indicative of increased apoptosis. These results suggest that BPA exposure in utero decreases the testosterone concentration by decreasing steroidogenic enzymes (StAR, CYP11A1, and 3-HSD). Furthermore, BPA exposure increases the apoptosis of germ cells, which is associated with proapoptotic changes in the levels of Bcl-2 and Bax.

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