Abstract Title:

Study of the Effect of Bisphenol A on Oxidative Stress in Children with Autism Spectrum Disorders.

Abstract Source:

Indian J Clin Biochem. 2018 Apr ;33(2):196-201. Epub 2017 Jun 5. PMID: 29651211

Abstract Author(s):

Fateheya M Metwally, Hend Rashad, Hala M Zeidan, Ayman Kilany, Ehab R Abdol Raouf

Article Affiliation:

Fateheya M Metwally


The role of bisphenol A (BPA) in autism was investigated in 49 children (mean age = 5.950 ± 1.911 years) with autism spectrum disorders (ASDs) and 40 comparable age and sex matched children used as controls (mean age = 5.333 ± 2.279 years). In addition, 8-Hydroxydeoxyguanosine (8-oxodG) was also studied as a biomarker of oxidative stress in the same set of two selected groups. The results showed that both BPA and 8-oxodG were significantly higher in children with autism than those of control children (values = 0.025 and 0.0001, respectively). There were positive correlations between both BPA and 8-oxodG with ASDs severity ( = 0.400 and 0.805, respectively), these correlations were highly significant (values = 0.004 and 0.001, respectively). There was a significance positive correlation between BMI and BPA, but the correlation between BMI and 8-oxodG was not significant in children with autism. The observed results revealed that BPA may increase oxidative stress resulting in mitochondrial dysfunctionthat affecting the behavior and functioning of ASDs children.

Study Type : Human Study

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