Abstract Title:

Antidepressant-like deliverables from the sea: evidence on the efficacy of three different brown seaweeds via involvement of monoaminergic system.

Abstract Source:

Biosci Biotechnol Biochem. 2017 Jul ;81(7):1369-1378. Epub 2017 Apr 13. PMID: 28406051

Abstract Author(s):

Pirzada Jamal Ahmed Siddiqui, Adnan Khan, Nizam Uddin, Saima Khaliq, Munawwer Rasheed, Shazia Nawaz, Muhammad Hanif, Ahsana Dar

Article Affiliation:

Pirzada Jamal Ahmed Siddiqui


Brown seaweeds exhibit several health benefits in treating and managing wide array of ailments. In this study, the antidepressant-like effect of methaolic extracts from Sargassum swartzii (SS), Stoechospermum marginatum (SM), and Nizamuddinia zanardinii (NZ) was examined in forced swimming test (FST), in rats. Oral administration of SS, SM, and NZ extract (30-60 mg/kg) exhibited antidepressant-like activity in FST by reducing immobility time as compared to control group, without inducing significant change in ambulatory behavior in open field test. In order to evaluate the involvement of monoaminergic system, rats were pretreated with the inhibitor of brain serotonin stores p-chlorophenylalanin (PCPA), dopamine (SCH23390 and sulpiride), and adrenoceptor (prazosin and propranolol) antagonists. Rats receiving treatment for 28 days were decapitated and brains were analyzed for monoamine levels. It may be concluded that the extracts of SS, SM, and NZ produces antidepressant-like activity via modulation of brain monoaminergic system in a rat model.

Study Type : Animal Study

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