Abstract Title:

Effect of Brussels sprouts on oxidative DNA-damage in man.

Abstract Source:

Cancer Lett. 1997 Mar 19 ;114(1-2):127-30. PMID: 9103270

Abstract Author(s):

H Verhagen, A de Vries, W A Nijhoff, A Schouten, G van Poppel, W H Peters, H van den Berg

Article Affiliation:

H Verhagen


The effect of consumption of Brussels sprouts on the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) into human urine was investigated. Ten non-smoking volunteers (five males and five females) were randomly assigned to two groups. Five volunteers started on a diet of 300 g of glucosinolate-free vegetables whereas the other five consumed 300 g of Brussels sprouts per day. After 1 week dietary regimes were reversed. Levels of 8-oxodG in 24-h urine samples were measured by high-performance liquid chromatography. In four of five males a reduction in 8-oxodG was found, whereas in the fifth male the 8-oxodG excretion was high in the control period and was even much higher in the sprouts period. In females no effect of consumption of Brussels sprouts on excretion of 8-oxodG was found. Our previous and present findings support the results of epidemiologic studies that consumption of brassica vegetables may diminish cancer risk.

Study Type : Human Study

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