Abstract Title:

New steroidal constituents of the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells.

Abstract Source:

Chem Pharm Bull (Tokyo). 1998 Feb;46(2):298-303. PMID: 9501465

Abstract Author(s):

Y Mimaki, M Kuroda, A Kameyama, A Yokosuka, Y Sashida


Phytochemical examination of the underground parts of Ruscus aculeatus has led to the isolation of a total of twelve steroidal saponins, including seven new ones. The structures of the new saponins were determined by spectroscopic analysis and chemical evidence. The furostanol saponin, having a diglycoside moiety modified with a (2S,3S)-2-hydroxy-3-methylpentanoic acid group and an acetic acid group, and its corresponding spirostanol saponin exhibited cytostatic activity on leukemia HL-60 cells.

Study Type : In Vitro Study

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