Butylated hydroxytoluene (BHT) is associated hemorrhagic toxicosis in rats. - GreenMedInfo Summary
Haemorrhagic toxicosis in rats given butylated hydroxytoluene.
Acta Pharmacol Toxicol (Copenh). 1981 Jul;49(1):14-20. PMID: 7336960
Vascular permeability, platelet function, blood coagulation and fibrinolytic activity were examined in Sprague-Dawley male rats given 1.20% butylated hydroxytoluene (BHT) in the diet for 1 week. BHT significantly increased the leakage of Evans blue from blood into epididymus. BHT inhibited the ADP-induced platelet aggregation and decreased the platelet factor 3 availability. Plasma prothrombin, factors IX, X, VII and VIII were decreased in rats given BHT. Fibrinolytic activity was little influenced by BHT-feeding.