Abstract Title:

Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia.

Abstract Source:

Phytother Res. 2016 Apr ;30(4):613-7. Epub 2016 Jan 20. PMID: 26787366

Abstract Author(s):

Flávia Cristina Fernandes Pimenta, Mateus Feitosa Alves, Martina Bragante Fernandes Pimenta, Silvia Adelaide Linhares Melo, Anna Alice Figueirêdo de Almeida, José Roberto Leite, Liana Clébia de Morais Pordeus, Margareth de Fátima Formiga Melo Diniz, Reinaldo Nóbrega de Almeida

Article Affiliation:

Flávia Cristina Fernandes Pimenta


The bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive procedure causing anxiety-associated symptoms. The present study assessed the effect of Citrus aurantium L. essential oil on the treatment of anxiety, in the moment that precedes the collection of medullary material in patients with chronic myeloid leukemia (CML). Volunteers from both sexes were divided into groups receiving either the C. aurantium essential oil through inhalation, diazepam (10 mg), or the placebo. The evaluation was performed through psychometric scales [State-Trait Anxiety Inventory (STAI)] and physiological measurements (blood pressure and cardiac and respiratory frequency). Inhalation of C. aurantium was associated with a decrease in the STAI-S scores, suggesting ananxiolytic effect. In support of these results, a change in all the physiological measurements was observed in the group exposed to C. aurantium. In the diazepam group, only the diastolic pressure decreased, and no effect was observed in the placebo group. Therefore, the results showed that C. aurantium exhibits an anxiolytic effect and reduces the signs and symptoms associated with anxiety in patients with CML.

Study Type : Human Study

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