Article Publish Status: FREE
Abstract Title:

Xanthine Oxidase Inhibitory Potential, Antioxidant and Antibacterial Activities of(L.) Link Fruiting Body.

Abstract Source:

Medicines (Basel). 2019 Jan 29 ;6(1). Epub 2019 Jan 29. PMID: 30699961

Abstract Author(s):

Tran Ngoc Quy, Tran Dang Xuan

Article Affiliation:

Tran Ngoc Quy


is a medicinal mushroom and has been extensively used as a folk medicine in East Asia. In this study, the separation of constituents involved in xanthine oxidase (XO) inhibitory, antioxidant and antibacterial properties ofwas conducted.The aqueous residue of this fungus was extracted by methanol and then subsequently fractionated by hexane, chloroform, ethyl acetate and water. The ethyl acetate extract possessed the highest XO inhibitory and antioxidant activities was separated to different fractions by column chromatography. Each fraction was then subjected to anti-hyperuricemia, antioxidant and antibacterial assays.The results showed that the CM8 fraction exhibited the strongest XO inhibitory activity (the lowest IC: 62.82μg/mL), followed by the CM10 (IC: 68.04μg/mL) and the CM7 (IC: 86.78μg/mL). The level of XO inhibition was proportional to antioxidant activity. In antibacterial assay, the CM9 and CM11 fractions showed effective antibacterial activity (MIC values: 15⁻25 mg/mL and 10⁻25 mg/mL, respectively). Results from gas chromatography-mass spectrometry (GC-MS) analyses indicated that cordycepin was the major constituent in the CM8 and CM10 fractions.This study revealed thatwas beneficial for treatment hyperuricemia although in vivo trials on compounds purified from this medicinal fungus are needed.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.