Abstract Title:

Oral supplementation with cocoa extract reduces UVB-induced wrinkles in hairless mouse skin.

Abstract Source:

J Invest Dermatol. 2016 Feb 5. Epub 2016 Feb 5. PMID: 26854493

Abstract Author(s):

Jong-Eun Kim, Dasom Song, Junil Kim, Jina Choi, Jong Rhan Kim, Hyun-Sun Yoon, Jung-Soo Bae, Mira Han, Sein Lee, Ji Sun Hong, Dayoung Song, Seong-Jin Kim, Myoung-Jin Son, Sang-Woon Choi, Jin Ho Chung, Tae-Aug Kim, Ki Won Lee

Article Affiliation:

Jong-Eun Kim


Cacao beans contain various bioactive phytochemicals that could modify the pathogeneses of certain diseases. Here, we report that oral administration of cacao powder (CP) attenuates UVB-induced skin wrinkling by the regulation of genes involved in dermal matrix production and maintenance. Transcriptome analysis revealed that 788 genes are down- or up-regulated in the CP supplemented group, compared to the UVB-irradiated mouse skin controls. Among the differentially-expressed genes, cathepsin G and serpin B6c play important roles in UVB-induced skin wrinkle formation. Gene regulatory network analysis also identified several candidate regulators responsible for the protective effects of CP supplementation against UVB-induced skin damage. CP also elicited anti-wrinkle effects via inhibition of UVB-induced MMP-1 expression in both the human skin equivalent model and human dermal fibroblasts (HDFs). Inhibition of UVB-induced AP-1 via CP supplementation is likely to affect the expression of MMP-1. CP supplementation also down-regulates the expression of cathepsin G in HDFs. 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, a major in vivo metabolite of CP, showed effects similar to CP supplementation. These results suggest that cacao extract may offer a protective effect against photoaging by inhibiting the breakdown of dermal matrix, which leads to an overall reduction in wrinkle formation.

Study Type : Animal Study

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