Abstract Title:

Anti-HIV and vitamin C-synergized radical scavenging activity of cacao husk lignin fractions.

Abstract Source:

In Vivo. 2008 May-Jun;22(3):327-32. PMID: 18610744

Abstract Author(s):

Hiroshi Sakagami, Kazue Satoh, Haruka Fukamachi, Takeshi Ikarashi, Ai Shimizu, Kazuyoshi Yano, Taisei Kanamoto, Shigemi Terakubo, Hideki Nakashima, Hideo Hasegawa, Akiko Nomura, Katsuaki Utsumi, Masaji Yamamoto, Yuuichi Maeda, Kenji Osawa

Article Affiliation:

Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan. [email protected]


Cacao husk lignin fractions, prepared by acid precipitation and 50% ethanol precipitation showed unexpectedly higher anti-human immunodeficiency virus (HIV) activity, as compared with the corresponding fractions from the cacao mass, amounting to the level comparable with that of popular anti-HIV compounds. The cacao husk lignin fractions also showed anti-influenza virus activity, but did not show antibacterial activity. The cacao husk lignin fractions synergistically enhanced the superoxide anion and hydroxyl radical scavenging activity of vitamin C. The cacao husk lignin fractions stimulated nitric oxide generation by mouse macrophage-like cells, to a level higher than that attained by lipopolysaccharide (LPS). The present study suggests the functionality of cacao husk lignin fractions as complementary alternative medicine.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.