The Impact of Propolis Factor Caffeic Acid Phenethyl-Ester on the Cerebral Vasospasm and Early Brain Damage in the Exparimentally Induced Subarachnoid Hemorrhage on Rats.
World Neurosurg. 2020 Mar 18. Epub 2020 Mar 18. PMID: 32200016
Mahmut Necdet Palaz
AIM: CAPE, a phenolic compound, besides being one of the biologically active components of propolis, is a compound with antioxidant, antiinflammatory, antiviral, reperfusion damage prevention, immune stimulant and carcinostatic, anticancer properties. The aim of this study was to investigate the possible effects of CAPE on cerebral vasospasm and early brain injury, which were experimentally administered intraperitoneally in rats with subarachnoid hemorrhage.
MATERIAL AND METHODS: 32 Wistar Albino rats weighing 200-300 grams were used in our study. The rats divided into three groups namely as Control group (n = 10), subarachnoid hemorrhage group (n = 11) and subarachnoid hemorrhage + CAPE group (n = 11) were evaluated according to the Ischemia index in hippocampal CA3 regions and the morphometric analysis of basilar artery diameter after being sacrified at the end of 72th hour.
RESULTS: A significant difference was found between group-1 and group-2 for the CA-3 region, it was concluded that early brain damage occurred after subarachnoid hemorrhage. When the neuronal damage in CA-3 region was evaluated between group-2 and group-3, a statistically significant difference was found between the groups. There was a statistically significant difference between group-1 and group-3 in terms of ischemia detection.
CONCLUSION: It was shown that CAPE has a preventive effect on early brain injury after SAH and has a positive effect on reducing cerebral vasospasm. Our study is the first study in the literature showing that CAPE inhibits ischemic brain injury following SAH.