Article Publish Status: FREE
Abstract Title:

The effects of multi mineral-vitamin D and vitamins (C+E) supplementation in the prevention of preeclampsia: An RCT.

Abstract Source:

Int J Reprod Biomed (Yazd). 2017 May ;15(5):273-278. PMID: 28744522

Abstract Author(s):

Milad Azami, Tayebe Azadi, Sepidezahra Farhang, Shoobo Rahmati, Khadijeh Pourtaghi

Article Affiliation:

Milad Azami


BACKGROUND: Several studies have reported the uncertain role of multi-minerals and vitamins in the prevention of preeclampsia.

OBJECTIVE: The present study aims to investigate the effect of multimineral-vitamin D supplements (calcium, magnesium, zinc and Vitamin D) and vitamins (C+ E) in the prevention of preeclampsia.

MATERIALS AND METHODS: In this randomized clinical trial, 90 pregnant women were divided into three groups: group A received Ferrous sulfate (1 tablet/day) + one tablet of Claci-care multimineral-vitamin D containing 800mg calcium, 200mg magnesium, 8mg zinc and 400 IU Vitamin D3 per day; group B received Ferrous sulfate (1 tablet/day) + 250 mg vitamin C + 55 mg vitamin E; and the controls received only one Ferrous sulfate tablet daily.

RESULTS: The incidence of preeclampsia in group A was significantly lower than the control group (p=0.03), while there was no significant difference between group B and controls (p=0.50), as well as groups A and B (p=0.063). The incidence of neonatal complications in the group A was significantly lower than the control group (p=0.01), while there was no significant difference between group B and control (p=0.48).

CONCLUSION: According to the results, calcium, magnesium, and zinc supplements have a significant effect on the prevention of preeclampsia. In addition, prescription of multimineral-vitamin D during pregnancy can be a low-cost and affordable way to reduce the incidence of preeclampsia in women who are at high risk of preeclampsia.

Study Type : Human Study

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