Abstract Title:

Inhibition of Western-diet induced hyperproliferation and hyperplasia in mouse colon by two sources of calcium.

Abstract Source:

Carcinogenesis. 1995 Nov;16(11):2685-9. PMID: 7586187

Abstract Author(s):

F Richter, H L Newmark, A Richter, D Leung, M Lipkin

Article Affiliation:

Irving Weinstein Laboratory for Gastrointestinal Cancer Prevention, Gastroenterology and Nutrition Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.


A Western-style diet containing high-fat and phosphate, and low calcium and vitamin D was fed to mice for 20 weeks. Starting at week 8, subgroups of animals received the Western-style diet supplemented by two different calcium sources: tricalcium phosphate and calcium citrate malate. Hyperproliferation (increased [3H]thymidine-labelled cells/colonic crypt) and hyperplasia (increased total epithelial cells/crypt) developed in the sigmoid colon after 8 weeks of feeding the Western-style diet confirming previous results, and these were reversed at later periods by the addition of the two calcium sources to the Western-style diet. Findings indicate that the modified colonic epithelial cell hyperproliferation and hyperplasia which have been associated with subsequent development of colonic neoplasia, are induced in mice fed a Western-style diet, and the addition of calcium to the diet inhibited their development in the colonic mucosa.

Study Type : Animal Study

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