Abstract Title:

HIV-1 inhibition by extracts of Clusiaceae species from Mexico.

Abstract Source:

Curr Eye Res. 2010 Apr;35(4):335-51. PMID: 15187447

Abstract Author(s):

Maira Huerta-Reyes, Maria del Carmen Basualdo, Lucio Lozada, Manuel Jimenez-Estrada, Carmen Soler, Ricardo Reyes-Chilpa

Article Affiliation:

Department of Natural Products, Institute of Chemistry, National University of Mexico, Mexico D F, Mexico.


The organic plant extracts of 21 species of Clusiaceae from Mexico were screened for anti HIV-1 reverse transcriptase activity in a non-radioactive immuno colorimetric assay. The extracts of 5 species (23.8%) exhibited significant inhibition (>or =70%) of HIV-1 RT activity; of these, only 4 extracts showed reduced toxicity to human lymphocytic MT2 cells and were further tested as inhibitors of HIV-1 IIIb/LAV replication in a cellular system. The best extracts were Calophyllum brasiliense (hexane) and Clusia quadrangula (CH(2)Cl(2)-MeOH) which inhibited HIV-1 RT (IC(50)=29.6 microg/ml and 42 microg/ml), and showed an EC(50)=92.5 microg/ml and 91 microg/ml, respectively, on MT2 cells. However, only Calophyllum brasiliense hexane extract showed significant inhibition on viral replication (ED(50)=37.1 microg/ml), while Clusia quadrangula was less active (ED(50)=124 microg/ml). These results support the idea that plant extracts represent a valuable source of potential anti HIV compounds.

Study Type : In Vitro Study

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