Abstract Title:

In vivo antitumor and antimetastatic activities of camptothecin encapsulated with N-trimethyl chitosan in a preclinical mouse model of liver cancer.

Abstract Source:

Cancer Lett. 2010 Nov 1 ;297(1):56-64. Epub 2010 May 23. PMID: 20546992

Abstract Author(s):

Lina Zhou, Xingyi Li, Xiancheng Chen, Zhiyong Li, Xianping Liu, Shengtao Zhou, Qian Zhong, Tao Yi, Yuquan Wei, Xia Zhao, Zhiyong Qian

Article Affiliation:

Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, People's Republic of China.


Application of camptothecin (CPT) is hampered due to its extreme water insolubility and unpredictable side effects. Therefore, it is essential to establish an efficient and safe protocol for the administration of camptothecin against tumor growth and metastasis. Here, we encapsulated camptothecin with N-trimethyl chitosan (CPT-TMC) and tested it on BALB/c mice subcutaneously injected with murine hepatocellular carcinoma cells at the hindlimb feet pad. CPT-TMC effectively inhibited tumor growth and lymphatic metastasis, prolonged survival time, yet without apparent toxic effects. Thus, CPT-TMC may provide a novel and effective therapeutic strategy against human advanced hepatic cancer without conspicuous systemic toxic effects.

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