Abstract Title:

Cannabidiol impairs fear memory reconsolidation in female rats through dorsal hippocampus CB1 but not CB2 receptor interaction.

Abstract Source:

Eur Neuropsychopharmacol. 2022 Aug 29 ;64:7-18. Epub 2022 Aug 29. PMID: 36049316

Abstract Author(s):

Jaqueline M Franzen, Felipe Vanz, Isabel Werle, Francisco S Guimar√£es, Leandro J Bertoglio

Article Affiliation:

Jaqueline M Franzen


Women present increased susceptibility to anxiety- and stress-related disorders compared to men. A potentially promising pharmacological-based strategy to regulate abnormal aversive memories disrupts their reconsolidation stage after reactivation and destabilization. Male rodent findings indicate that cannabidiol (CBD), a relatively safe and effective treatment for several mental health conditions, can impair the reconsolidation of aversive memories. However, whether and how CBD influences it in females is still unknown. The present study addressed this question in contextually fear-conditioned female rats. We report that systemically administered CBD impaired their reconsolidation, reducing freezing expression for over a week. This action was restricted to a time when the reconsolidation presumably lasted (

Study Type : Animal Study

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