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Abstract Title:

Cannabidiol for Rapid Eye Movement Sleep Behavior Disorder.

Abstract Source:

Mov Disord. 2021 Mar 22. Epub 2021 Mar 22. PMID: 33754375

Abstract Author(s):

Carlos M O de Almeida, Manuelina M C Brito, Nayanne B Bosaipo, Angela V Pimentel, Vitor Tumas, Antonio W Zuardi, Jose A S Crippa, Jaime E C Hallak, Alan L Eckeli

Article Affiliation:

Carlos M O de Almeida

Abstract:

BACKGROUND: REM sleep behaviour disorder (RBD) is a common non-motor feature of Parkinson's disease (PD). Cannabidiol (CBD) is one of the main non-psychoactive components of Cannabis sativa and may represent an alternative route for treating RBD.

OBJECTIVE: This study assessed the efficacy and safety of CBD for RBD in PD.

METHODS: We conducted a phase II/III, double-blind, placebo-controlled clinical trial in 33 patients with RBD and PD. Patients were randomized 1:1 to CBD in doses of 75 to 300mg or matched capsules placebo and were followed up for 14 weeks. The primary outcomes were the frequency of nights with RBD, CGI-I, and CGI-S.

RESULTS: CBD showed no difference to placebo for primary outcomes. Regarding secondary outcomes, we observed a significant improvement in average sleep satisfaction from the 4th to 8th week in the CBD versus placebo group with P = 0.049 and P = 0.038, respectively.

CONCLUSION: CBD, as an adjunct therapy, showed no reduction in RBD manifestations in PD patients. A transient improvement in sleep satisfaction with a dose of 300mg has been noted.© 2021 International Parkinson and Movement Disorder Society.

Study Type : Human Study

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