Abstract Title:

Evaluation of the role of the cannabidiol system in an animal model of ischemia/reperfusion kidney injury.

Abstract Source:

Rev Bras Ter Intensiva. 2015 Dec ;27(4):383-389. PMID: 26761477

Abstract Author(s):

Rodrigo Zon Soares, Francieli Vuolo, Dhébora Mozena Dall'Igna, Monique Michels, José Alexandre de Souza Crippa, Jaime Eduardo Cecílio Hallak, Antonio Waldo Zuardi, Felipe Dal-Pizzol

Article Affiliation:

Rodrigo Zon Soares

Abstract:

OBJECTIVE: This work aimed to investigate the effects of the administration of cannabidiol in a kidney ischemia/reperfusion animal model.

METHODS: Kidney injury was induced by 45 minutes of renal ischemia followed by reperfusion. Cannabidiol (5mg/kg) was administered immediately after reperfusion.

RESULTS: Ischemia/reperfusion increased the IL-1 and TNF levels, and these levels were attenuated by cannabidiol treatment. Additionally, cannabidiol was able to decrease lipid and protein oxidative damage, but not the nitrite/nitrate levels. Kidney injury after ischemia/reperfusion seemed to be independent of the cannabidiol receptor 1 and cannabidiol receptor 2 (CB1 and CB2) expression levels, as there was no significant increase in these receptors after reperfusion.

CONCLUSION: The cannabidiol treatment had a protective effect against inflammation and oxidative damage in the kidney ischemia/reperfusion model. These effects seemed to be independent of CB1/CB2 receptor activation.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.