Abstract Title:

Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival.

Abstract Source:

Amyotroph Lateral Scler Other Motor Neuron Disord. 2005 Sep;6(3):182-4. PMID: 16183560

Abstract Author(s):

Patrick Weydt, Soyon Hong, Anke Witting, Thomas Möller, Nephi Stella, Michel Kliot

Article Affiliation:

Department of Neurology, University of Washington, Seattle, WA 98195, USA. [email protected]

Abstract:

Therapeutic options for amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, remain limited. Emerging evidence from clinical studies and transgenic mouse models of ALS suggests that cannabinoids, the bioactive ingredients of marijuana (Cannabis sativa) might have some therapeutic benefit in this disease. However, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the predominant cannabinoid in marijuana, induces mind-altering effects and is partially addictive, compromising its clinical usefulness. We therefore tested whether cannabinol (CBN), a non-psychotropic cannabinoid, influences disease progression and survival in the SOD1 (G93A) mouse model of ALS. CBN was delivered via subcutaneously implanted osmotic mini-pumps (5 mg/kg/day) over a period of up to 12 weeks. We found that this treatment significantly delays disease onset by more than two weeks while survival was not affected. Further research is necessary to determine whether non-psychotropic cannabinoids might be useful in ameliorating symptoms in ALS.

Study Type : Animal Study

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