Abstract Title:

Cluster attacks responsive to recreational cannabis and dronabinol.

Abstract Source:

Headache. 2009 Jun;49(6):914-6. Epub 2009 Feb 11. PMID: 19220500

Abstract Author(s):

Matthew S Robbins, Sara Tarshish, Seymour Solomon, Brian M Grosberg

Article Affiliation:

Montefiore Headache Center, Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract:

Pharmacological preparations of cannabinoid compounds have a variety of therapeutic uses in medicine, including different pain syndromes, but have not been previously reported as beneficial for cluster headache. We present a patient with cluster headache who was refractory to multiple acute and preventive medications but successfully aborted his attacks with recreational marijuana use; subsequent use of dronabinol provided equally effective pain relief. The beneficial effect may be related to the high concentration of cannabinoid receptors in the hypothalamus, which has been implicated as a site of dysfunction in neuroimaging studies of patients with cluster headache.

Study Type : Human: Case Report
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