Abstract Title:

Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity.

Abstract Source:

Mol Nutr Food Res. 2014 Dec ;58(12):2274-85. Epub 2014 Oct 9. PMID: 25204550

Abstract Author(s):

Yun-Ji Kim, Jong-Sang Kim, Young Rok Seo, Jung Han Yoon Park, Myung-Sook Choi, Mi-Kyung Sung

Article Affiliation:

Yun-Ji Kim


SCOPE: This study determined the efficacy of carnosic acid (CA) for suppressing colon carcinogenesis associated with excess adiposity.

METHODS AND RESULTS: Cell growth regulation by CA was evaluated in HT-29 colon adenocarcinoma cells cocultured with 3T3-L1 adipocytes. To determine the in vivo efficacies, male A/J mice were divided into four groups and fed one of the following experimental diets for 11 wk: 15% fat, 45% fat, 45% fat + 0.01% CA, or 45% fat + 0.02% CA. Azoxymethane was administered at the beginning of experimental diet and two cycles of dextran sodium sulfate were supplied 1 wk after the azoxymethane injection. The proliferation of HT-29 cells cocultured with 3T3-L1 cells was significantly higher than proliferation of control cells (p<0.05). CA treatment suppressed the growth of cocultured HT-29 cells through cell cycle arrest and enhanced apoptosis by inhibiting leptin receptor (Ob-R) signaling, including Akt and extracellular signal-regulated kinase (ERK) phosphorylation. CA supplementation in vivo decreased the number of colon tumors and reduced circulating concentrations of leptin, adiponectin, insulin, and insulin-like growth factor 1. Colonic expression of Ob-R, insulin receptor (IR), p-Akt, p-ERK, B-cell lymphoma extra large (Bcl-xL), and cyclinD1 protein was also suppressed in animals fed CA.

CONCLUSION: CA appears to alleviate adipocity-related acceleration of colon tumor formation.

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