Abstract Title:

Carnosic acid protects starvation-induced SH-SY5Y cell death through Erk1/2 and Akt pathways, autophagy, and FoxO3a.

Abstract Source:

Int J Food Sci Nutr. 2016 Jul 19:1-6. Epub 2016 Jul 19. PMID: 27435046

Abstract Author(s):

Sachi Shibata, Hiroyuki Ishitobi, Shigeru Miyaki, Tomohiro Kawaoka, Tomoko Kayashima, Kiminori Matsubara

Article Affiliation:

Sachi Shibata


Carnosic acid (CA) is recognized as a unique neuroprotective compound in the herb rosemary, since it induces expression of antioxidant enzymes including heme oxygenase-1 (HO-1),γ-glutamylcysteine synthase (γ-GCS), and glutathione S-transferase (GST) via activation of nuclear factor erythroid 2-related factor 2 (Nrf2), which is a nuclear transcription factor. In this study, we examined the cytoprotective effects of CA against starvation. We found that CA protected starvation-induced SH-SY5Y cell death by activating Akt and extracellular signal-regulated kinase 1/2 (Erk1/2). Interestingly, CA induced moderate autophagy and dephosphorylation of a transcriptional factor, the forkhead box protein O3a (FoxO3a). These effects of CA play an important role in cytoprotection.

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