Abstract Title:

Antiproliferative effects of Ceratonia siliqua L. on mouse hepatocellular carcinoma cell line.

Abstract Source:

Fitoterapia. 2002 Dec;73(7-8):674-84. PMID: 12490228

Abstract Author(s):

L Corsi, R Avallone, F Cosenza, F Farina, C Baraldi, M Baraldi

Abstract:

Extracts from pods and leaves of carob (Ceratonia siliqua L.) were tested for their ability to inhibit cell proliferation of mouse hepatocellular carcinoma cell line (T1). The two extracts showed a marked alteration of T1 cell proliferation in a dose-related fashion reaching the maximal effect at 1 mg/ml. Moreover, we demonstrated that leaf and pod extracts were able to induce apoptosis in T1 cell lines after 24-h treatment mediating a direct activation of the caspase 3 pathway. HPLC analysis revealed the presence of gallic acid, (-) epigallocatechin-3-gallate and (-) epicatechin-3-gallate in pod and leaf extracts, compounds well known to exert antiproliferative effects. Their concentration reached 6.28 mg/g in carob leaves and 1.36 mg/g in carob pods extract. The discovery that carob pod and leaf extracts contained antiproliferative agents could be of practical importance in the development of functional foods and/or chemopreventive drugs. Copyright 2002 Elsevier Science B.V.

Study Type : Animal Study
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