Abstract Title:

Carotenoids supplementation and inflammation: a systematic review and meta-analysis of randomized clinical trials.

Abstract Source:

Crit Rev Food Sci Nutr. 2021 May 17:1-17. Epub 2021 May 17. PMID: 33998846

Abstract Author(s):

Fatemeh Hajizadeh-Sharafabad, Elham Sharifi Zahabi, Mahsa Malekahmadi, Rasoul Zarrin, Mohammad Alizadeh

Article Affiliation:

Fatemeh Hajizadeh-Sharafabad


The aim of this study was to perform a systematic review and meta-analysis on randomized controlled trials investigating the effects of carotenoids on selected inflammatory parameters. PubMed, SCOPUS, and Web of science were searched from inception until April 2021. The random-effect model was used to analyze data and the overall effect size was computed as weighted mean difference (WMD) and corresponding 95% of confidence interval (CI). A total of 26 trials with 35 effect sizes were included in this meta-analysis. The results indicated significant effects of carotenoids on C-reactive protein (CRP) (WMD:‒0.54 mg/L, 95% CI: ‒0.71, ‒0.37, < 0.001), and interleukin-6 (IL-6) (WMD: ‒0.54 pg/mL, 95% CI: ‒1.01, ‒0.06, = 0.025), however the effect on tumor necrosis factor-alpha (TNF-α) was not significant (WMD: ‒0.97 pg/ml, 95% CI: ‒1.98, 0.03, = 0.0.059). For the individual carotenoids, astaxanthin, (WMD: ‒0.30 mg/L, 95% CI: ‒0.51, ‒0.09, = 0.005), lutein/zeaxanthin (WMD: ‒0.30 mg/L, 95% CI: ‒0.45, ‒0.15, < 0.001), and β-cryptoxanthin (WMD: ‒0.35 mg/L, 95% CI: ‒0.54, ‒0.15, < 0.001) significantly decreased CRP level. Also, only lycopene (WMD: ‒1.08 pg/ml, 95%CI: ‒2.03, ‒0.12, = 0.027) led to a significant decrease in IL-6. The overall results supported possible protective effects of carotenoids on inflammatory biomarkers.

Study Type : Meta Analysis, Review

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