Abstract Title:

Protective effect ofL. seed on oxidative stress and cognitive impairment induced by chronic alcohol consumption in mice.

Abstract Source:

Food Sci Biotechnol. 2018 Oct ;27(5):1475-1484. Epub 2018 Sep 19. PMID: 30319858

Abstract Author(s):

Seung Hak Choi, Ah Young Lee, Chan Hum Park, Yu Su Shin, Eun Ju Cho

Article Affiliation:

Seung Hak Choi


Chronic alcohol consumption induces damage to the brain that can cause various forms of dementia. An abundance of acetaldehyde is produced by excessive alcohol consumption and accumulates in the body to induce oxidative stress, apoptosis, and inflammation in neuronal cells, which results in learning and cognitive decline. In the present study, C57BL/N mice were orally administered alcohol (16%) andL. seed (CTS) (100 and 200 mg/kg/day). Behavioral experiments showed that memory and cognitive abilities were significantly higher in the CTS groups than the alcohol-treated control group in the T-maze test, novel object recognition test, and Morris water maze test. In addition, CTS inhibited alcohol-induced lipid peroxidation and nitric oxide production in the brain, kidney, and liver. Moreover, alcohol increased acetylcholinesterase activity in the brain, but this was significantly decreased by the administration of CTS. Therefore, CTS may play role in the prevention of alcohol-related dementia.

Study Type : Animal Study

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