Abstract Title:

[Bilateral optic neuropathy with loss of vision after an influenza vaccination in a patient suffering from mixed connective tissue disease].

Abstract Source:

Rev Neurol (Paris). 2010 Dec ;166(12):1024-7. Epub 2010 Nov 10. PMID: 21067788

Abstract Author(s):

M Laffon-Pioger, F Rocher, M Cohen, S Chanalet, P Thomas, C Lebrun

Article Affiliation:

M Laffon-Pioger


BACKGROUND: Optic neuropathy is a rare adverse reaction to vaccination.

CASE REPORT: A 62-year-old-woman was hospitalized for bilateral optic neuropathy with loss of vision. The symptoms occurred 15 days after a seasonal influenza vaccination. Her past medical history included a mixed connective tissue disease with no immunosuppressive treatment for several years. Investigations did not reveal any obvious cause and the hypothesis of post-influenza vaccination bilateral optic neuropathy was retained although a complication of the connective tissue disease complication could not be ruled out. The patient was given intravenous methylprednisolone 1g daily. At a cumulative dose of 8 g, oral steroids were given and tapered off.

DISCUSSION: Few similar case reports have been described in literature. The causal link between vaccination and optic neuropathy thus remains to be confirmed. Clinicians should however consider this etiology.

Study Type : Human: Case Report

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Sayer Ji
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