Abstract Title:

Experimental endometriosis reduction in rats treated with Uncaria tomentosa (cat's claw) extract.

Abstract Source:

Eur J Obstet Gynecol Reprod Biol. 2010 Oct 26. Epub 2010 Oct 26. PMID: 21030132

Abstract Author(s):

João Nogueira Neto, Tarcísio Mota Coelho, Guilherme Carneiro Aguiar, Laura Rosa Carvalho, Ana Gisélia Portela de Araújo, Manuel João B C Girão, Eduardo Schor

Article Affiliation:

Experimental Surgery Laboratory of the University Hospital of the Federal University of Maranhão, UFMA, São Luís (MA), Brazil; Gynecology Department, Pelvic Pain and Endometriosis Unit, Federal University of São Paulo/Escola Paulista de Medicina, São Paulo (SP), Brazil.


OBJECTIVE: The aim of this study was to analyze the macroscopic and histological changes that occur in experimental endometriosis after treatment with Uncaria tomentosa. STUDY DESIGN: Experimental endometriosis was induced in twenty-five female Wistar rats. After three weeks, 24 animals developed grade III experimental endometriosis and were divided into two groups. Group "U" received U. tomentosa extract orally (32mg/day), and group "C" (control group) received a 0.9% sodium chloride solution orally (1ml/100g of body weight/day). Both groups were treated with gavage for 14 days. At the surgical intervention and after the animal was euthanized, the implant volume was calculated with the following formula: [4π (length/2)×(width/2)×(height/2)/3]. The autotransplants were removed, dyed with hematoxylin-eosin, and analyzed by light microscopy. The Mann-Whitney test was used for the independent samples, and the Wilcoxon test analyzed the related samples, with a significance level of 5%. RESULTS: The difference between the initial average volumes of the autotransplants was not significant between the groups (p=0.18). However, the final average volumes were significantly different between the groups (p=0.001). There was a significant increase (p=0.01) between the initial and final average volumes inthe control group, and treatment with the U. tomentosa caused a marked reduction in the growth over time (p=0.009). Histologically, in the experimental group (n=10) six rats had a well-preserved epithelial layer, three had mildly preserved epithelium, and one had poorly preserved epithelium. The epithelial layer occasionally presented sporadic epithelial cells. The control group (n=12) presented seven cases (58.3%) of well-preserved epithelial cells and five cases (41.7%) of mildly preserved epithelial cells. CONCLUSIONS: Cat's claw extract appears to be a promising alternative for treating endometriosis.

Study Type : Animal Study
Additional Links

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.