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Article Publish Status: FREE
Abstract Title:

Celastrol and Resveratrol ModulateGenes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like Cells.

Abstract Source:

Cancers (Basel). 2022 Mar 8 ;14(6). Epub 2022 Mar 8. PMID: 35326523

Abstract Author(s):

Helena Moreira, Anna Szyjka, Justyna Grzesik, Katarzyna Pelc, Magdalena Żuk, Anna Kulma, Fathi Emhemmed, Christian D Muller, Kazimierz Gąsiorowski, Ewa Barg

Article Affiliation:

Helena Moreira

Abstract:

Metastatic colorectal cancer (CRC) remains a hard-to-cure neoplasm worldwide. Its curability declines with successive lines of treatment due to the development of various cancer resistance mechanisms and the presence of colorectal cancer stem cells (CSCs). Celastrol and resveratrol are very promising phytochemicals for colon cancer therapy, owing to their pleiotropic activity that enables them to interact with various biological targets. In the present study, the anticancer activities of both compounds were investigated in metastatic colon cancer cells (LoVo cells) and cancer stem-like cells (LoVo/DX). We showed that celastrol is a very potent anti-tumor compound against metastatic colon cancer, capable of attenuating CSC-like cells at the molecular and cellular levels. In contrast, resveratrol has a much greater effect on colon cancer cells that are expressing standard sensitivity to anticancer drugs, than on CSC-like cells. In addition, both polyphenols have different influences on the expression ofgenes, which seems to be at least partly related to their anti-tumor activity.

Study Type : In Vitro Study

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