Abstract Title:

Treatment of women's sexual dysfunction using Apium graveolens L. Fruit (celery seed): A double-blind, randomized, placebo-controlled clinical trial.

Abstract Source:

J Ethnopharmacol. 2021 Jan 10 ;264:113400. Epub 2020 Sep 22. PMID: 32971161

Abstract Author(s):

Kamran Hessami, Tahereh Rahnavard, Ayda Hosseinkhani, Sara Azima, Mehrab Sayadi, Azam Faraji, Massoumeh Emamghoreishi, Homeira Vafaei, Anahita Hessami, Leila Foroughinia, Maasumeh Kaviani, Shohreh Roozmeh, Nasrin Asadi

Article Affiliation:

Kamran Hessami


ETHNOPHARMACOLOGICAL RELEVANCE: Traditional manuscripts refer to plants such as Apium graveolens L. Fruit (celery seed), which could be used to improve sexual function among women. Since that time, local herbal shops in Iran continue to provide this herb as a natural aphrodisiac product.

AIM OF THE STUDY: This study aimed to evaluate the efficacy and safety of celery seed for the treatment of female sexual dysfunction.

METHODS AND MATERIALS: In this parallel, randomized, double-blinded clinical trial, 80 women were assigned to receive either 500 mg of celery seed or placebo 3 times a day for a period of 6 weeks (n = 40 per group). The female sexual function index (FSFI) questionnaire was used to evaluate women's sexual function before and after treatment.

RESULTS: At the end of the sixth week, an improvement in the total FSFI score was significantly greater in celery seed-treated women than those receiving the placebo (P < 0.001). Increased total FSFI score is mainly contributed by improvement in the sexual desire (p < 0.001), arousal (p < 0.001), lubrication (p < 0.001), and pain (p = 0.033) domains at the endpoint of study. No serious side effects were noticed in both groups during the study period.

CONCLUSION: It seems that celery seed improved sexual function in women and could be used as a safe, well-tolerated, and effective herbal medicine in women with sexual dysfunction.

Study Type : Human Study
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