Abstract Title:

Comparison of vaccine effectiveness against influenza hospitalization of cell-based and egg-based influenza vaccines, 2017-2018.

Abstract Source:

Vaccine. 2019 Sep 16 ;37(39):5807-5811. Epub 2019 Aug 22. PMID: 31445771

Abstract Author(s):

Katia J Bruxvoort, Yi Luo, Bradley Ackerson, Hilary C Tanenbaum, Lina S Sy, Ashesh Gandhi, Hung Fu Tseng

Article Affiliation:

Katia J Bruxvoort


Egg-based influenza vaccines could be less effective than cell-based vaccine due to adaptive mutations acquired for growth. We conducted a test-negative case-control study at Kaiser Permanente Southern California to assess vaccine effectiveness (VE) against hospitalization for laboratory-confirmed influenza during 2017-2018. Among the 1186 cases and 6946 controls, 74% and 59%, respectively, were ages ≥ 65 years. For any influenza, the adjusted relative VE of cell-based vaccine versus egg-based vaccines was 43% (95% CI: -45% to 77%) for patients ages < 65 years and 6% (95% CI: -46% to 39%) for patients ages ≥ 65 years. For influenza A(H3N2), the adjusted relative VE was 61% (95% CI: -63% to 91%) for patients ages < 65 years and -4% (95% CI: -70% to 37%) for patients ages ≥ 65 years. Statistically significant protection against influenza hospitalization of cell-based vaccine compared to egg-based vaccines was not observed, but further studies in additional influenza seasons are warranted.

Study Type : Human Study

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