Centella asiatica leaf extract may be useful as an alternative therapy against H. pylori infection. - GreenMedInfo Summary

infection is associated with an increased risk of developing upper gastrointestinal tract diseases. However, treatment failure is a major cause of concern mainly due to possible recurrence of infection, the side effects, and resistance to antibiotics. The aim of this study was to investigate the activities ofleaf extract (CAE) againstbothand. The minimum inhibitory concentrations (MICs) against 55 clinically isolated strains ofwere tested using an agar dilution method. The MICs of CAE ranged from 0.125 mg/mL to 8 mg/mL, effectiveness in inhibitinggrowth was 2 mg/mL. The anti-effects of CAEwere also examined in-infected C57BL/6 mice. CAE was orally administrated once daily for 3 weeks at doses of 50 mg/kg and 250 mg/kg. CAE at the 50 mg/kg dose significantly reducedcolonization in mice gastric mucosa. Our study provides novel insights into the therapeutic effects of CAE againstinfection, and it suggests that CAE may be useful as an alternative therapy.