Abstract Title:

Central nervous system and limb anomalies in case reports of first-trimester statin exposure.

Abstract Source:

N Engl J Med. 2004 Apr 8 ;350(15):1579-82. PMID: 15071140

Abstract Author(s):

Robin J Edison, Maximilian Muenke


The cholesterol-lowering statin drugs are contraindicated in pregnancy1; therefore, few data exist regarding their safety in human gestation. We reviewed 178 cases of first-trimester statin exposure reported to the Food and Drug Administration (FDA) from 1987 through 2001 for patterns suggesting possible drug-related effects on embryogenesis. After the exclusion of cases involving first-trimester elective or spontaneous abortions (46 and 42 cases, respectively), pregnancy loss due to maternal illness (15), fetal genetic disorders (3), transient neonatal disorders (5), or loss to follow-up (15), 52 cases were considered evaluable.

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Study Type : Human: Case Report

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