Abstract Title:

Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice.

Abstract Source:

Int Immunopharmacol. 2013 Apr ;15(4):666-70. Epub 2013 Mar 25. PMID: 23535020

Abstract Author(s):

Taek Joon Yoon, Sue Jung Lee, Eun Young Kim, Eun Hee Cho, Tae Bong Kang, Kwang-Won Yu, Hyung Joo Suh

Article Affiliation:

Taek Joon Yoon


Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity. This activity was assessed through the levels of the IgE Ab produced in response to an allergen (OVA). The administration of C-HE prophylactically inhibited the systemic anaphylactic shock induced by compound 48/80 in mice. The oral administration of C-HE significantly reduced the total IgE levels in mice and slightly affected the production of IgG1. Furthermore, spleen cell cultures harvested from OVA-sensitised mice that had received C-HE orally showed a significant increase in Th1-derived responses (IFN-γ production). Therefore, our results suggest that the chaga mushroom extract may be used as an anti-allergic functional food.

Study Type : Animal Study

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