Abstract Title:

Influence of dietary supplementation with Bacillus-fermented adlay on lipid metabolism, antioxidant status and intestinal microflora in hamsters.

Abstract Source:

J Sci Food Agric. 2011 Sep ;91(12):2271-6. Epub 2011 May 26. PMID: 21618546

Abstract Author(s):

Chung-Yi Wang, Hsin-Tang Lin, She-Ching Wu

Article Affiliation:

Chung-Yi Wang


BACKGROUND: The effects of polished and dehulled Bacillus-fermented adlay on lipid metabolism, antioxidant status and intestinal microflora were examined in hyperlipidaemic hamsters fed a high-cholesterol diet.

RESULTS: Hamsters administered Bacillus-fermented adlay experienced significantly reduced (P<0.05) serum and hepatic total cholesterol (by 37-43% and 42-49% respectively) and triglyceride (by 22-27% and 30-35% respectively) levels compared with the high-cholesterol group. Lower low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratios in serum and increased cholesterol (by 47-52%) and triglyceride (by 40-47%) contents in faeces were also observed. Bacillus-fermented adlay lowered the levels of thiobarbituric acid-reactive substances, thus increasing total antioxidant and superoxide dismutase activities. In particular, polished Bacillus-fermented adlay had satisfactory antioxidant activity, similar to that of commercially available natto. Moreover, hamsters fed Bacillus-fermented adlay harboured greater populations of lactic acid bacteria, few coliforms and little Clostridium perfringens.

CONCLUSION: This study has shown that changes in lipid metabolism, antioxidant status and intestinal microflora can be greatly modulated by Bacillus-fermented adlay, suggesting potential novel approaches to the treatment of primary cardiovascular and intestinal diseases.

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