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Article Publish Status: FREE
Abstract Title:

Chemical Constituents of the Leaves of Butterbur () and Their Anti-Inflammatory Effects.

Abstract Source:

Biomolecules. 2019 11 29 ;9(12). Epub 2019 Nov 29. PMID: 31795455

Abstract Author(s):

Jin Su Lee, Miran Jeong, Sangsu Park, Seung Mok Ryu, Jun Lee, Ziteng Song, Yuanqiang Guo, Jung-Hye Choi, Dongho Lee, Dae Sik Jang

Article Affiliation:

Jin Su Lee

Abstract:

Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur () along with six known compounds. The chemical structures of lignansandwere elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Petasitesin A and cimicifugic acid D showed significant inhibitory effects on the production of both prostaglandin E2 (PGE) and NO in RAW264.7 macrophages. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by compoundin RAW264.7 cells. Furthermore, compoundsandexhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.

Study Type : In Vitro Study

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