Chemical constituents of the leaves of butterbur and their anti-inflammatory effects. - GreenMedInfo Summary
Chemical Constituents of the Leaves of Butterbur () and Their Anti-Inflammatory Effects.
Biomolecules. 2019 11 29 ;9(12). Epub 2019 Nov 29. PMID: 31795455
Jin Su Lee
Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur () along with six known compounds. The chemical structures of lignansandwere elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Petasitesin A and cimicifugic acid D showed significant inhibitory effects on the production of both prostaglandin E2 (PGE) and NO in RAW264.7 macrophages. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by compoundin RAW264.7 cells. Furthermore, compoundsandexhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.