Article Publish Status: FREE
Abstract Title:

Chemical Constituents of the Leaves of Butterbur () and Their Anti-Inflammatory Effects.

Abstract Source:

Biomolecules. 2019 11 29 ;9(12). Epub 2019 Nov 29. PMID: 31795455

Abstract Author(s):

Jin Su Lee, Miran Jeong, Sangsu Park, Seung Mok Ryu, Jun Lee, Ziteng Song, Yuanqiang Guo, Jung-Hye Choi, Dongho Lee, Dae Sik Jang

Article Affiliation:

Jin Su Lee


Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur () along with six known compounds. The chemical structures of lignansandwere elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Petasitesin A and cimicifugic acid D showed significant inhibitory effects on the production of both prostaglandin E2 (PGE) and NO in RAW264.7 macrophages. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by compoundin RAW264.7 cells. Furthermore, compoundsandexhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.