Abstract Title:

[Hepatotoxicity of antineoplastic agents].

Abstract Source:

Vestn Ross Akad Med Nauk. 2009(11):17-20. PMID: 20017402

Abstract Author(s):

G V Karpova, T I Fomina, T V Vetoshkina, T Iu Dubskaia, L A Ermolaeva, A A Churin


The influence of various antineoplastic preparations (farmorubicin, paclitaxel, etoposide, platidiam) on morphological and functional status of the liver in experimental animals was studied. It is shown, that all these antineoplastic drugs possess strong hepatotoxic activity and thereby cause toxic hepatitis and increase activity of hepatic enzymes. Biochemical parameters were normalized within 30 days after treatment whereas morphological changes persisted somewhat longer.

Study Type : Animal Study

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