Chlorella supplementation detoxifies heterocyclic amines in young Korean adults. - GreenMedInfo Summary
Detoxification of chlorella supplement on heterocyclic amines in Korean young adults.
Environ Toxicol Pharmacol. 2015 Jan ;39(1):441-6. Epub 2014 Dec 3. PMID: 25590673
Heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) have been established as carcinogenic chemicals in Western diet. This study was performed to estimate HCA exposure levels in Korean daily life and to assess the ability of Chlorella vulgaris to detoxify carcinogenic HCAs in a randomized, double blind, placebo-controlled crossover study with chlorella supplement (N=6, all females, age: 27.17±7.73yr) for 2 weeks. We analyzed HCAs in hydrolyzed urine specimens using LC/TOF-MS. As results, urinary levels of MeIQx, PhIP, and IQx-8-COOH were 323.36±220.11ng/L, 351.59±254.93ng/L, and 130.85±83.22ng/L, respectively. Effects of chlorella to reduce urinary MeIQx were marginally significant(before, 430±226.86pg/mL vs. after, 174.45±101.65pg/mL: 0.05