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Abstract Title:

Chlorogenic acid abates male reproductive dysfunction in arsenic-exposed mice via attenuation of testicular oxido-inflammatory stress and apoptotic responses.

Abstract Source:

Chem Biol Interact. 2020 Nov 23:109333. Epub 2020 Nov 23. PMID: 33242462

Abstract Author(s):

Manal F El-Khadragy, Wafa A Al-Megrin, Suliman Alomar, Afrah F Alkhuriji, Dina M Metwally, Shahenda Mahgoub, Hatem K Amin, Ola A Habotta, Ahmed E Abdel Moneim, Rasha S Albeltagy

Article Affiliation:

Manal F El-Khadragy

Abstract:

Arsenic, a major environmental pollutant of global concern, is well-known for its reproductive toxicity. In this study, the protective potential of chlorogenic acid (CGA), a caffeoylquinic acid isomer abundantly found in many plants, was investigated against sodium arsenite (NaAsO)-induced testicular dysfunctions. Adult male Swiss mice were either administered NaAsOalone at 5 mg kgor co-treated with CGA at 100 mg kgor 200 mg kgbody weight for 4 weeks. Results showed that NaAsO-treated mice exhibited marked declines in testes weight, sperm count, and viability accompanied by decreases in sexual hormonal levels. Moreover, NaAsOtoxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde. Further, elevations in inflammatory cytokines (IL-1, TNF-α, and IL-6) together with the up-regulation of pro-apoptotic biomarkers (Bax and caspase- 3) and down-regulation of anti-apoptotic Bcl-2 were observed in NaAsOintoxication. Immunohistochemical analysis of testis sections of NaAsO-treated mice showed high caspase-3 expression. These findings were well supported with testicular histopathological examination. However, pretreatment of mice with CGA resulted in noteworthy improvements in testicular damage induced by arsenic in a dose-dependent manner possibly mediated by the Nrf2 signaling pathway. Conclusively, CGA counteracted arsenic-induced testicular injury through its antioxidant, anti-inflammatory, and anti-apoptotic properties. Therefore, CGA could serve as a favorable intervention in the alleviation of arsenic-induced reproductive toxicity.

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