n/a
Article Publish Status: FREE
Abstract Title:

Chlorogenic acid alleviates obesity and modulates gut microbiota in high-fat-fed mice.

Abstract Source:

Food Sci Nutr. 2019 Feb ;7(2):579-588. Epub 2019 Jan 28. PMID: 30847137

Abstract Author(s):

Zhengyu Wang, Ka-Lung Lam, Jiamiao Hu, Shenghan Ge, Arong Zhou, Baodong Zheng, Shaoxiao Zeng, Shaoling Lin

Article Affiliation:

Zhengyu Wang

Abstract:

To evaluate the anti-obesity effects of chlorogenic acid (CGA), the mice were fed a high-fat diet (HFD) upon chlorogenic acid treatment for 6 weeks. The results showed administration of chlorogenic acid (150 mg per kg per day) remarkably promoted body loss, reduced lipid levels in plasma and altered mRNA expression of lipogenesis and lipolysis related genes in adipose tissue. Moreover, chlorogenic acid also reversed the HFD-induced gutmicrobiota dysbiosis, including significantly inhibiting the growth ofand raising the growth of. Overall, the amelioration of HFD-induced gut microbiota dysbiosis by chlorogenic acid may contribute, at least partially, to its beneficial effects on ameliorating HFD-induced obesity.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.