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Article Publish Status: FREE
Abstract Title:

Chlorogenic Acid Protects against Advanced Alcoholic Steatohepatitis in Rats via Modulation of Redox Homeostasis, Inflammation, and Lipogenesis.

Abstract Source:

Nutrients. 2021 Nov 20 ;13(11). Epub 2021 Nov 20. PMID: 34836410

Abstract Author(s):

Vyacheslav Buko, Ilya Zavodnik, Grażyna Budryn, Małgorzata Zakłos-Szyda, Elena Belonovskaya, Siarhei Kirko, Dorota Żyżelewicz, Agnieszka Zakrzeska, Aliaksei Bakunovich, Viktor Rusin, Valentina Moroz

Article Affiliation:

Vyacheslav Buko

Abstract:

The aim of this study was to evaluate the therapeutic effects of chlorogenic acid (CGA) in rats with advanced alcoholic steatohepatitis. The rats were fed on a high-fat diet and gavaged with ethanol (4 g/kg) for 8 weeks. The livers of ethanol-treated rats showed steatosis; necrosis and mononuclear infiltration; and significant upregulation of the mRNA expression of the prooxidant (Cyp2e1, iNos), lipogenic (Srebp1, Acc), proinflammatory (Tlr4, Nf-κb, TnfA, Il-1B, and Il-6), and profibrogenic (TgfB, Col1, VegfA) genes. Simultaneously, a downregulation of level ofandwas observed, which was accompanied by increased serum transaminase, TnfA, and serum and liver triglycerides levels. CGA administration (40 and 80 mg/kg, 8 weeks) to ethanol-fed group reduced the liver expression levels ofand, whereas it markedly enhanced the expression of,, and. CGA at both doses downregulated the expressions of lipogenic, proinflammatory, and profibrogenic genes, while the expression ofwas lowered only after the higher dose of CGA. The higher dose of CGA efficiently prevented the progression of alcohol-induced steatosis and reduced inflammation through regulation of the expression of genes encoding the proteins involved in the Tlr4/Nf-κB signaling pathway and fibrosis. The study revealed hepatoprotective and anti-inflammatory effects of CGA through the regulation of expression of genes encoding Cyp2e1/Nrf2 involved in oxidative stress modulation. These results demonstrate CGA as a therapeutic candidate for the prevention and treatment of alcoholic steatohepatitis.

Study Type : Animal Study

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