Abstract Title:

Hormonal changes with cholesterol reduction: a double-blind pilot study.

Abstract Source:

J Clin Pharm Ther. 2004 Feb ;29(1):71-3. PMID: 14748901

Abstract Author(s):

T Ormiston, O M Wolkowitz, V I Reus, R Johnson, F Manfredi

Article Affiliation:

Department of Internal Medicine, Santa Clara Valley Medical Center, San Jose, CA, USA. [email protected]


BACKGROUND: The lowering of high serum cholesterol levels may be associated with increased non-cardiac mortality due to behavioral changes, although such endpoints are likely rare.

OBJECTIVE: This current study sought to determine if hormonal changes accompany pharmacologically induced decreases in serum cholesterol levels.

METHOD: Cholesterol, dopamine, homovanillic acid (HVA), serotonin, 5-HIAA, testosterone, cortisol and pregnenolone were measured at baseline and after 4 weeks of treatment.

RESULTS: Subjects' cholesterol levels significantly declined within 4 weeks. Concomitant significant increase in dopamine and HVA were noted.

CONCLUSION: Although this study is limited in size, it raises the possibility that cholesterol-lowering drug treatment is associated with hormonal perturbations.

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Sayer Ji
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