Article Publish Status: FREE
Abstract Title:

Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners.

Abstract Source:

Arq Bras Cardiol. 2017 Mar ;108(3):212-216. PMID: 28443964

Abstract Author(s):

Célia Regina de Oliveira Bittencourt, Maria Cristina de Oliveira Izar, Carolina Nunes França, Valdir Lauro Schwerz, Rui Manuel Dos Santos Póvoa, Francisco Antonio Helfenstein Fonseca

Article Affiliation:

Célia Regina de Oliveira Bittencourt


BACKGROUND: The effects of chronic exposure to exercise training on vascular biomarkers have been poorly explored.

OBJECTIVE: Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners and healthy controls.

METHODS: Twenty-five half-marathon runners and 24 age- and gender-matched healthy controls were included in the study. EPCs (CD34+/KDR+, CD133+/KDR+, and CD34+/CD133+), EMP (CD51+) and PMP (CD42+/CD31+) were quantified by flow-cytometry. All blood samples were obtained after 12 h of fasting and the athletes were encouraged to perform their routine exercises on the day before.

RESULTS: As compared with controls, the CD34+/KDR+ EPCs (p=0.038) and CD133+/KDR+ EPCs (p=0.018) were increased, whereas CD34+/CD133+ EPCs were not different (p=0.51) in athletes. In addition, there was no difference in MPs levels between the groups.

CONCLUSION: Chronic exposure to exercise in professional runners was associated with higher percentage of EPCs. Taking into account the similar number of MPs in athletes and controls, the study suggests a favorable effect of exercise on these vascular biomarkers.

Study Type : Human Study

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