Proton Pump Inhibitors Accelerate Endothelial Senescence.
Circ Res. 2016 May 10. Epub 2016 May 10. PMID: 27166251
RATIONALE: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal and neurological morbidity.
OBJECTIVE: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI induced vascular dysfunction.
METHODS AND RESULTS: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length.
CONCLUSIONS: Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal and neurological morbidity and mortality.