Article Publish Status: FREE
Abstract Title:

Proton Pump Inhibitors Accelerate Endothelial Senescence.

Abstract Source:

Circ Res. 2016 May 10. Epub 2016 May 10. PMID: 27166251

Abstract Author(s):

Gautham Yepuri, Roman Sukhovershin, Timo Z Nazari-Shafti, Michael Petrascheck, Yohannes T Ghebre, John P Cooke

Article Affiliation:

Gautham Yepuri


RATIONALE: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal and neurological morbidity.

OBJECTIVE: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI induced vascular dysfunction.

METHODS AND RESULTS: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length.

CONCLUSIONS: Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal and neurological morbidity and mortality.

Study Type : Human In Vitro

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