Chrysanthemum indicum L. ethanol extract reduces high-fat diet-induced obesity in mice. - GreenMedInfo Summary
Chrysanthemum indicum L. ethanol extract reduces high-fat diet-induced obesity in mice.
Exp Ther Med. 2018 Jun ;15(6):5070-5076. Epub 2018 Apr 10. PMID: 29844801
The present study was undertaken to investigate the mechanism behind the anti-obesity effect of the 50% ethanol extract ofL. flowers (CIEE) in a mouse model of high-fat diet (HFD)-induced obesity. Male C57BL/6J mice (six mice in each group) were administered CIEE (8, 40 and 200 mg/kg) for 6 weeks while being fed with a HFD.(GC) was used as the positive control and was administered in the same manner as CIEE. Results demonstrated that oral administration of CIEE significantly reduced body weight, epididymal white adipose tissue (EWAT), liver weight and serum levels of total cholesterol and triglyceride (P<0.05). In addition, CIEE reduced serum leptin and increased adiponectin levels. CIEE significantly downregulated peroxisome proliferator-activated receptorγ (PPARγ), CCAAT/enhancer-binding protein-α and fatty acid synthase expression levels in EWAT, and upregulated the protein expression of PPARα in liver tissue of HFD-fed obese mice (P<0.05). These results suggested thatL. flowers may be a potentially effective therapeutic agent for obesity and its associated complications.