Article Publish Status: FREE
Abstract Title:

Inhibition of dengue virus replication by diisopropyl chrysin-7-yl phosphate.

Abstract Source:

Sci China Life Sci. 2016 Apr 22. Epub 2016 Apr 22. PMID: 27106619

Abstract Author(s):

Jiang Du, Zhe Chen, Ting Zhang, Jianmin Wang, Qi Jin

Article Affiliation:

Jiang Du


Dengue fever is a tropical disease and caused by dengue virus (DENV), which is transmitted by mosquitoes and infects about 400 million people annually. With the development of international trade and travel, China is facing a growing threat. Over 40 thousands of people were infected during the 2014 DENV outbreak in Guangdong. Neither licensed vaccine nor therapeutic drug has been available. In this report, we isolated two clinical DENV strains. The full-length genome was sequenced and characterized. We also applied a flavonoid, CPI, into an anti-DENV assay. Replication of viral RNA and expression of viral protein was all strongly inhibited. These results indicated that CPI may serve as potential protective agents in the treatment of patients with chronic DENV infection.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)

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