Abstract Title:

Chrysin, a natural flavonoid enhances steroidogenesis and steroidogenic acute regulatory protein gene expression in mouse Leydig cells.

Abstract Source:

J Endocrinol. 2008 May;197(2):315-23. PMID:18434361

Abstract Author(s):

Kuladip Jana, Xiangling Yin, Randolph B Schiffer, Jau-Jiin Chen, Akhilesh K Pandey, Douglas M Stocco, Paula Grammas, Xingjia Wang


Excerpt: "During the aging process of males, testosterone biosynthesis declines in testicular Leydig cells resulting in decreases in various physiological functions. To explore the possibility of delaying the decline using food supplements, we have studied steroidogenic effects of a natural flavonoid, chrysin, in mouse Leydig cells. Chrysin dramatically increased cyclic AMP (cAMP)-induced steroidogenesis in MA-10 mouse Leydig tumor cells. This result was confirmed using Leydig cells isolated from mouse testes.."

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