Abstract Title:

Cinnamaldehyde induces apoptosis and reverses epithelial-mesenchymal transition through inhibition of Wnt/β-catenin pathway in non-small cell lung cancer.

Abstract Source:

Int J Biochem Cell Biol. 2017 Jan 16 ;84:58-74. Epub 2017 Jan 16. PMID: 28093328

Abstract Author(s):

Cunen Wu, Yuwen Zhuang, Shan Jiang, Fang Tian, Yuhao Teng, Xu Chen, Peiqiu Zheng, Shenlin Liu, Jinyong Zhou, Jian Wu, Ruiping Wang, Xi Zou

Article Affiliation:

Cunen Wu


Cinnamaldehyde, the main chemical component of the essential oil separated from the traditional herb Cinnamomum cassia, has been demonstrated to be an efficient cytotoxic agent against several human cancers. The present experiment showed that cinnamaldehyde dose-dependently depresses the proliferation of three types of NSCLC cells and induces cell apoptosis in vitro and in vivo. Moreover, cinnamaldehyde attenuated CoCl2-induced EMT and decreased matrix metalloprotease (MMP) family while the in vivo study showed the same trend. Mechanistically, cinnamaldehyde imitated the suppressive effect of XAV939 on cell motility and EMT which could be impaired by LiCl. Collectively, our research demonstrated for the first time that cinnamaldehyde is able to inhibit NSCLC cell growth by inducing apoptosis and reverse EMT through terminating Wnt/β-catenin pathway, which might supply further insight into cinnamaldehyde-mediated anti-tumor effect against NSCLC for better prognosis.

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