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Article Publish Status: FREE
Abstract Title:

Cinnamaldehyde Mitigates Atherosclerosis Induced by High-Fat DietModulation of Hyperlipidemia, Oxidative Stress, and Inflammation.

Abstract Source:

Oxid Med Cell Longev. 2022 ;2022:4464180. Epub 2022 Jun 21. PMID: 35774377

Abstract Author(s):

Basma S Ismail, Basant Mahmoud, Eman S Abdel-Reheim, Hanan A Soliman, Tarek M Ali, Basem H Elesawy, Mohamed Y Zaky

Article Affiliation:

Basma S Ismail

Abstract:

Atherosclerosis is a disease in which plaque builds up inside arteries. Cinnamaldehyde (Ci) has many biological properties that include anti-inflammatory and antioxidant activities. Thus, this study was designed to explore the protective effect of Ci against atherosclerosis induced by a high-fat diet (HFD) in Wistar rats. Atherosclerosis was induced by an oral administration of an HFD for 10 weeks. Atherosclerosis-induced rats were supplemented with Ci at a dose of 20 mg/kg bw dissolved in 0.5% dimethyl sulfoxide (DMSO), daily by oral gavage for the same period. Rats were divided into three groups of 10 rats each fed with (a) ND, (b) HFD, and (c) HFD+Ci, daily for 10 weeks. Treatment of rats with Ci significantly reduced the elevated levels of serum total cholesterol (T.Ch), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-Ch), very low-density lipoprotein-cholesterol (VLDL-Ch), and free fatty acids (FFAs) and significantly increased the lowered levels of high-density lipoprotein-cholesterol (HDL-Ch) level. Ci ameliorated the increased cardiovascular risk indices 1 and 2 and the decreased antiatherogenic index. Moreover, Ci reduced the elevated serum creatine kinase (CK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) activities. Ci also improved the heart antioxidant activities by decreasing malondialdehyde (MDA) and increasing glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and glutathione peroxidase (Gpx) activities. Furthermore, the supplementation with Ci downregulated the mRNA expression levels of interleukin-1(IL-1), interleukin-6 (IL-6), interleukin-17 (IL-17), and tumor necrosis factor-(TNF-). Thus, Ci successfully elicited a therapeutic impact against atherosclerosis induced by HFDits hypolipidemic, antioxidant, and anti-inflammatory actions.

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